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Asymmetric Synthesis of trans-3-Alkoxyamino-4-Oxygenated-2-Piperidones Mediated by Transition-Metal-Free Dual C-H Oxidation and Its CAL-B-Assisted Enzymatic Resolution
| dc.rights.license | http://creativecommons.org/licenses/by/4.0 - Atribución | es_MX |
| dc.contributor.author | MARINA ARGELIA ORTEGA ROJAS | es_MX |
| dc.contributor.author | JONATHAN ROMAN VALDEZ CAMACHO | es_MX |
| dc.contributor.author | Jaime Escalante García | es_MX |
| dc.coverage.spatial | MEX - México | es_MX |
| dc.date | 2023-04-06 | |
| dc.date.accessioned | 2023-04-27T16:10:07Z | |
| dc.date.available | 2023-04-27T16:10:07Z | |
| dc.identifier.issn | 2073-4344 | |
| dc.identifier.uri | http://riaa.uaem.mx/handle/20.500.12055/3588 | |
| dc.description | A general chemo-enzymatic approach to synthesize both enantioenriched trans-3-alkoxyamino-4-oxy-2-piperidones, which are important scaffold for various naturally occurring alkaloids, is reported. To this end, a selective transition-metal-free dual C−H oxidation of piperidines mediated by the TEMPO oxoammonium cation (TEMPO+) was used, followed by enzymatic resolution of the corresponding alkoxyamino-2-piperidones with Candida antarctica lipase (CAL-B), to yield the title compounds in high enantiomeric excess (ee). The absolute configuration of both enantioenriched compounds was determined using chemical correlation and circular dichroism (CD) spectroscopy. The former method highlights the oxidative ring contraction of the trans-alkoxyamine-2-piperidone ring into its corresponding 2-pyrrolidinone. | es_MX |
| dc.format | pdf - Adobe PDF | es_MX |
| dc.language | eng - Inglés | es_MX |
| dc.publisher | MDPI Open Access Journals | es_MX |
| dc.relation.ispartof | Catalysts | es_MX |
| dc.relation.ispartofseries | 4 | es_MX |
| dc.relation.haspart | 13 | es_MX |
| dc.relation.uri | https://www.mdpi.com/2073-4344/13/4/703 | es_MX |
| dc.rights | openAccess - Acceso Abierto | es_MX |
| dc.subject | 2 - BIOLOGÍA Y QUÍMICA | es_MX |
| dc.subject.classification | trans-3-Alkoxyamino-4-oxygenated-2-piperidones, selective C−H oxidation, transition-metal-free, enzymatic resolution; CAL-B, deconstructive lactamization | es_MX |
| dc.subject.other | 23 - QUÍMICA | es_MX |
| dc.title | Asymmetric Synthesis of trans-3-Alkoxyamino-4-Oxygenated-2-Piperidones Mediated by Transition-Metal-Free Dual C-H Oxidation and Its CAL-B-Assisted Enzymatic Resolution | es_MX |
| dc.type | article - Artículo | es_MX |
| uaem.unidad | Centro de Investigaciones Químicas (CIQ) - Instituto de Investigación en Ciencias Básicas y Aplicadas (IICBA) - Centro de Investigaciones Químicas (CIQ) - Instituto de Investigación en Ciencias Básicas y Aplicadas (IICBA) | es_MX |
| dc.type.publication | publishedVersion | es_MX |
| dc.audience | researchers - Investigadores | es_MX |
| dc.audience | students - Estudiantes | es_MX |
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