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Chromatographic Techniques and Pharmacological Analysis as a Quality Control Strategy for Serjania triquetra a Traditional Medicinal Plant

dc.rights.licensehttp://creativecommons.org/licenses/by/4.0 - Atribuciónes_MX
dc.contributor.authorANGELICA BERENICE AGUILAR GUADARRAMAes_MX
dc.coverage.spatialMEX - Méxicoes_MX
dc.date2022
dc.date.accessioned2023-01-12T16:22:06Z
dc.date.available2023-01-12T16:22:06Z
dc.identifier.issn1424-8247
dc.identifier.urihttp://riaa.uaem.mx/handle/20.500.12055/3098
dc.descriptionSerjania triquetra is a medicinal plant widely used in traditional medicine for the treatment of urinary tract diseases, renal affections, and its complications. The population can buy this plant in folk markets as a raw material mixed with several herbal remedies or as a health supplement. On the market, two commercial presentations were found for the vegetal material; one had a bulk appearance and the other was marketed wrapped in cellophane bags (HESt-2, HESt-3). Nevertheless, the plant has not been exhaustively investigated and quality control techniques have not been developed. This research aimed to realize a phytochemical study using an authentic, freshly collected sample as a reference for S. triquetra (HESt-1), using the compounds identified. A method for the determination of preliminary chromatographic fingerprinting was developed. Additionally, the vasorelaxant effect from three samples was evaluated with ex vivo rat models. Thus, three hydroalcoholic extracts (HESt-1, HESt-2, and HESt-3) were prepared by maceration. A total of nine compounds were fully identified from HESt-1 after the extract was subjected to open-column chromatography. Seven metabolites were detected by gas chromatography, while ursolic acid (UA) and allantoin were isolated and identified using UPLC-MS and NMR, respectively. Three extracts were analyzed for their chromatographic fingerprint by UPLC-MS. Biological activity was explored by ex vivo rat aorta ring model to evaluate vasorelaxant activity. All extracts showed a vasorelaxant effect in a concentration-dependent and endothelium-dependent manner. S. triquetra vascular activity may be attributed to UA and allantoin compounds previously described in the literature for this activity.es_MX
dc.languageeng - Ingléses_MX
dc.publisherMDPI Open Access Journalses_MX
dc.relation.ispartofPharmaceuticalses_MX
dc.relation.ispartofseries1289es_MX
dc.relation.haspart15es_MX
dc.relation.urihttps://www.mdpi.com/1424-8247/15/10/1289es_MX
dc.rightsopenAccess - Acceso Abiertoes_MX
dc.subject2 - BIOLOGÍA Y QUÍMICAes_MX
dc.subject.classificationvasorelaxant activity; traditional medicine, ursolic acid; allantoin; NMR; UPLC-MS; CG-MS; blood pressurees_MX
dc.subject.other24 - CIENCIAS DE LA VIDAes_MX
dc.titleChromatographic Techniques and Pharmacological Analysis as a Quality Control Strategy for Serjania triquetra a Traditional Medicinal Plantes_MX
dc.typearticle - Artículoes_MX
uaem.unidadCentro de Investigaciones Químicas (CIQ) - Instituto de Investigación en Ciencias Básicas y Aplicadas (IICBA) - Centro de Investigaciones Químicas (CIQ) - Instituto de Investigación en Ciencias Básicas y Aplicadas (IICBA)es_MX
dc.type.publicationpublishedVersiones_MX
dc.audienceresearchers - Investigadoreses_MX


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    Artículos publicados por investigadores de la UAEM en revistas de investigación, sean éstas de la UAEM o de otras instituciones nacionales o extranjeras.

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